MOTS-c US vial by aminoscience for research use only: This synthetic 16-residue mitochondria-derived peptide acts as a highly specialized model sequence encoded natively inside the 12S rRNA locus of the mitochondrial genome, engineered purely for in-vitro assay frameworks. Preclinical investigators incorporate this non-nuclear genetic tool compound into cell culture lines to evaluate targeted mitochondrial-to-nuclear communication cascades and adaptive energy-sensing pathways. Stabilized via controlled freeze-drying limits inside a vacuum-sealed glass environment, this clean solid matrix safeguards primary peptide bonds to prevent premature sequence degradation during structured laboratory protocols.
•🔬1. Analytical Characterization & Metabolic Homeostasis
Securing absolute dataset reproducibility across repeat cell-based configurations demands rigid quality verification benchmarks before fluid reconstitution. Regular batch processing validation checkouts mandate third-party analysis inside accredited USA testing facilities to ensure a verified purity threshold greater than or equal to 98%. High-performance liquid chromatography (RP-HPLC) peak integrations isolate the main 16-amino-acid segment from process variables or truncated fractions, while mass spectrometry records match the theoretical mass near 2174 Da, confirming correct identity before structural loading.
•🧬2. MOTS-c Preclinical & Handling FAQ
•🎨What factors account for macroscopic shape variations in the dry MOTS-c solid preparation?
The gross physical appearance or density of the dry peptide cake within the sealed glass structure relies strictly on laboratory sublimation parameters and batch moisture extraction rates during automated synthesis runs. Certain vacuum-sealed lots compress into a solid plug configuration, while other identical batches present a softer, white powder configuration. High-precision screening workflows trust lot-specific mass calculations and HPLC chromatogram records, never macroscopic visual volume shifts within the vial boundaries.
•⏳What are the proper laboratory parameters for keeping reconstituted MOTS-c stable?
The introduction of appropriate research-grade solvents or laboratory-grade fluids changes the compound's thermodynamic profile, increasing kinetic fragility compared to its solid state. Following fluid introduction, prepared fluid peptide structures require immediate refrigeration between 2°C and 8°C. Keeping prepared solutions shielded from intense sunlight exposure protects structural chemical links, preserving functional potencies throughout an optimal 20 to 30-day assay window.
•📦Can dry MOTS-c solid vials survive ambient heat spikes during domestic shipping?
Yes, completely. Dry synthetic fragments packed under deep vacuum environments feature robust molecular stability traits. Experience logs record that un-reconstituted research vials can endure ambient room temperature fluctuations across standard domestic transit windows without suffering structural cleavage or lose purity limits, provided the parcel remains fully insulated from intense UV light exposure and heavy climate heat waves.
•📊3. MOTS-c Chemical Framework
| Chemical Identity: | MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c Synthetic Peptide) |
| Purity Benchmark: | ≥98% Pure Analytical Profile Verified via Accredited USA Laboratories |
| Molecular Profile: | Formula: C101H152N28O22S2 | Mass Weight: ~2174 Da | CAS Registry Number: 1627580-64-6 |
| Handling Protocols: | Oxidation-sensitive sequence due to 2 Methionine residues | Reconstitute via empirical design |
| Application Intention: | Synthesized Chemical Supplier Reagents for In-Vitro and Preclinical Research Only |
•🎓Preclinical & Scientific References
For verification of the biological mechanisms, amino acid modifications, and molecular traits cited in current cell line essays, investigators can review the independent peer-reviewed literature and reference trials:
- • Hruby, V. J., et al. (2002). Synthesis and analytical design of structural peptide variations for selective metabolic receptor targeting. Journal of Medicinal Chemistry, 45(14), 2845-2855.
- • Manning, M., et al. (2008). Automated synthesis protocols, cross-receptor design criteria, and structural longevity thresholds of synthetic peptide sequences. Journal of Medicinal Chemistry, 51(15), 4341-4352.
- • Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and mitochondrial-to-nuclear signaling pathways. Cell Metabolism, 21(3), 443-454.
⚠️ FDA DISCLAIMER: These products are intended strictly for laboratory research use only. They are not intended for human consumption, diagnostic, or therapeutic purposes. The statements on this website have not been evaluated by the Food and Drug Administration.
