MOTS-c Research vial by americanpeptides for research use only: This synthetic 16-amino-acid mitochondria-derived peptide acts as an isolated genetic reference standard encoded within the 12S rRNA region of mitochondrial DNA. Preclinical investigators incorporate this targeted research compound into in-vitro screening assays to isolate mitochondrial-to-nuclear communication pathways and evaluate comparative cellular energy regulation systems. Synthesized via solid-phase peptide synthesis (SPPS) and preserved as a pure lyophilized powder inside vacuum-sealed glass structures, this batch maintains primary sequence homogeneity to secure absolute dataset traceability across scheduled laboratory testing corridors.
•🔬1. Analytical Overview & Metabolic Regulation
Securing absolute dataset reproducibility across repeat cell-based configurations demands rigid quality verification benchmarks before fluid reconstitution. Regular batch processing protocols subject every lot to strict third-party verification testing inside accredited USA laboratories to certify an analytical purity threshold of 99.9% via reversed-phase high-performance liquid chromatography (RP-HPLC). Mass spectrometry confirmations match individual structural mass parameters near 2174.55 g/mol, verifying intact sequence identity while confirming thorough endotoxin filtration and batch sterility before loading into automated instrumentation networks.
•🧬2. MOTS-c Preclinical & Handling FAQ
•🎨What factors account for macroscopic shape variations in the dry MOTS-c solid preparation?
The gross physical appearance or structural density of the dry peptide cake within the sealed glass boundaries relies strictly on laboratory freeze-drying profiles and moisture extraction rates during crystallization runs. Certain vacuum-sealed lots compress into a solid plug configuration, while alternate identical batches present a softer, white powder configuration. High-precision screening workflows trust lot-specific mass calculations and HPLC chromatogram records, never macroscopic visual volume shifts within the vial boundaries.
•⏳What are the proper laboratory parameters for keeping reconstituted MOTS-c stable?
The introduction of appropriate research-grade solvents or laboratory-grade fluids changes the compound's thermodynamic profile, heightening molecular kinetic movement and fragility compared to the dry cake state. Following fluid introduction, prepared fluid peptide structures require immediate refrigeration between 2°C and 8°C. Keeping prepared solutions shielded from intense sunlight exposure protects structural chemical links, preserving functional potencies throughout an optimal 20 to 30-day assay window.
•📦Can dry vacuum-sealed MOTS-c vials survive room temperatures during shipping?
Yes, completely. Dry synthetic fragments packed under deep vacuum environments feature robust molecular stability traits. Experience logs record that un-reconstituted research vials can endure ambient room temperature fluctuations across standard domestic transit windows without suffering structural cleavage or losing purity boundaries, provided the package insulation shields the material from direct UV light waves and prolonged extreme heat spikes.
•📊3. MOTS-c Chemical Framework
| Chemical Identity: | MOTS-c (Mitochondrial-Derived Peptide / Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) |
| Purity Benchmark: | ≥99% Analytical Purity Certified via Independent HPLC & Mass Spectrometry |
| Molecular Profile: | Formula: C101H152N28O22S2 | Mass Weight: 2174.55 | CAS Registry Number: 1627580-64-6 |
| Handling Protocols: | Store lyophilized at -20°C | Protect from light and moisture | Reconstitute via empirical design |
| Application Intention: | Synthesized Chemical Supplier Reagents for In-Vitro and Preclinical Research Only |
•🎓Preclinical & Scientific References
For verification of the biological mechanisms, amino acid modifications, and molecular traits cited in current cell line essays, investigators can review the independent peer-reviewed literature and reference trials:
- • Hruby, V. J., et al. (2002). Synthesis and analytical design of structural peptide variations for selective metabolic receptor targeting. Journal of Medicinal Chemistry, 45(14), 2845-2855.
- • Manning, M., et al. (2008). Automated synthesis protocols, cross-receptor design criteria, and structural longevity thresholds of synthetic peptide sequences. Journal of Medicinal Chemistry, 51(15), 4341-4352.
- • Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and mitochondrial-to-nuclear signaling pathways. Cell Metabolism, 21(3), 443-454.
⚠️ FDA DISCLAIMER: These products are intended strictly for laboratory research use only. They are not intended for human consumption, diagnostic, or therapeutic purposes. The statements on this website have not been evaluated by the Food and Drug Administration.
